Patient presented with sudden painful erythematous lesions on the face and neck and was urgently referred to dermatology after initial clinical evaluation. Recent medication was discontinued due to suspected drug-related reaction.<\/p>\n
Workup included skin biopsy, complete blood count, and testing for antibodies, lupus anticoagulant, and serological markers. Oral corticosteroids were started for symptom control.<\/p>\n
Within 48 hours, lesions improved significantly and pain subsided. Laboratory results showed leukocytosis with neutrophilia, positive antibodies and lupus anticoagulant, while routine serology remained negative.<\/p>\n
Skin biopsy findings obtained later confirmed the diagnosis of Sweet syndrome.<\/p>\n
Sweet syndrome, also known as acute febrile neutrophilic dermatosis, is a rare inflammatory condition characterized by dense neutrophilic infiltration in the skin and sudden onset of painful erythematous papules or plaques.<\/p>\n
Its exact cause is unclear, but it is believed to involve cytokine-driven neutrophil activation. It is considered an immune-mediated hypersensitivity reaction associated with infections, malignancies, or drug exposure.<\/p>\n
Drug-induced cases are relatively common and may be linked to medications such as antibiotics, antiepileptics, contraceptives, antihypertensives, vaccines, and colony-stimulating factors. First-line treatment is oral corticosteroids, often producing rapid clinical improvement.<\/p>\n
Differential diagnosis includes urticaria, contact dermatitis, toxicoderma, and cutaneous lupus. Definitive diagnosis requires correlation of clinical presentation, laboratory findings, and histopathology to exclude systemic disease and guide appropriate therapy.<\/p>\n","protected":false},"excerpt":{"rendered":"
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